Notify patients that a house teaspoon is not really an accurate measuring unit and this kind of use could lead to overdosage and serious adverse reactions [see OVERDOSAGE (ten)]. For prescriptions wherever a measuring product is not furnished, a pharmacist can provide an proper calibrated measuring gadget and can offer Recommendations for measuring the correct dose.
Phenylephrine hydrochloride tested destructive within the in vitro bacterial reverse mutation assay, in vitro Chinese hamster ovary (CHO) cell chromosomal aberrations assay, and in vivo rat micronucleus assay. Phenylephrine hydrochloride was equivocal in the in vitro mouse lymphoma assay without metabolic activation; even so, a take a look at with metabolic activation was not done.
As a result of chance of respiratory depression, prevent the use of opioid antitussives, together with Promethazine with Codeine Oral Solution in sufferers with compromised respiratory function, people liable to respiratory failure, and in aged, cachectic, or debilitated clients.
Providing or giving away PROMETHAZINE VC WITH CODEINE ORAL SOLUTION may well harm Many others, and it is against the regulation. Convey to your healthcare service provider For those who have at any time abused or been depending on Alcoholic beverages, prescription medicines or Road prescription drugs.
If somebody has overdosed and has really serious symptoms for example passing out or difficulties respiratory, simply call 911. In any other case, contact a poison Management Heart without delay.
The codeine and promethazine in Promethazine VC with Codeine Oral Resolution may possibly enhance the frequency of seizures in clients with seizure Issues, and may improve the danger of seizures developing in other medical configurations connected with seizures.
Phenylephrine is metabolized mainly by monoamine oxidase and sulfotransferase from the intestinal wall and liver. There are two main metabolites, m-hydroxymandelic acid and sulfate conjugates, that happen to be regarded as not pharmacologically active.
When employed for an extended time, this medication may not operate likewise and will have to have different dosing. Speak with your health care provider if this medication stops Doing the job nicely.
Promethazine is metabolized with the liver to various inactive metabolites for example sulfoxides of promethazine, N-demethylpromethazine and various glucuronides.
The precise mechanism of motion of codeine together with other opiates is just not recognized; however, codeine is thought to act centrally within the cough center. In extreme doses, codeine will depress respiration.
Promethazine VC with Codeine Oral Solution is indicated for your temporary aid of coughs and upper respiratory symptoms, together with nasal congestion, linked with allergy or the popular cold in patients 18 many years of age and more mature.
Will not flush prescription drugs down the bathroom or pour them Promethazine With Codeine into a drain Unless of course instructed to do so. Properly discard this product when it is actually expired or now not wanted. Talk to your pharmacist or neighborhood waste disposal enterprise.
In case you are prescribed this medication on a daily agenda and miss a dose, take it when you bear in mind. Whether it is near the time of the next dose, skip the missed dose. Take your future dose with the normal time. Never double the dose to catch up.
Be certain that sufferers have an oral dosing dispenser that actions the appropriate volume in milliliters. Counsel patients regarding how to make the most of an oral dosing dispenser and properly measure the oral suspension as prescribed.